Dying Professor Teaches his Students How To Live

Lou Gehrig's disease hasn't stopped law professor Steven Gey's lessons

By John Barry, Times Staff Writer

TALLAHASSEE — Steven Gey's law students kept their part of the deal. Last Saturday morning, they swam, biked and ran in a triathlon for Lou Gehrig's disease research. They raised $50,000 for the third straight year.

In late afternoon, about 50 students and former students waited for professor Gey to keep his end of the bargain. In a sense, they hoped for him to complete — against all previous odds — his own kind of marathon.

They waited on his patio, beer iced and ready. They had a birthday cake. The cake with garish red icing itself seemed outrageously miraculous, another lesson for all of them. Their professor wasn't supposed to have a 53rd birthday.

The famous Florida State University constitutional law expert is in the third year of terminal illness. That's as long as anyone usually lives after a Lou Gehrig's diagnosis like his.

In the last year, he has nearly starved and suffocated. He lost half his house to Tropical Storm Fay. He lost use of his hands and arms. He even lost his identity to credit thieves.

The students have always had a deal with Gey. If you care, if you try, he has promised them, I'll help you become the kind of lawyers you need to be.

Now here they were on his porch, waiting for him to deliver on another promise.

They're young, and they don't know limits. How much can they expect of a dying teacher?

• • •

Steven Gey is more famous for legal scholarship than for dying. As an American Civil Liberties Union attorney and FSU law professor, he ranks among the nation's top defenders of separation of church and state, of scientific inquiry, of free speech. (His free speech reputation was tarnished only once. He stopped a restaurant chain from singing Happy Birthday To You — a copyright infringement. He has never lived it down.)

He is also famous for turning generations of youths into attorneys and judges.

Last spring, Gey nearly died from malnutrition. He had to give up teaching. He felt bitterly disappointed that the Bush administration had limited embryonic stem cell research for eight years. He felt that the limits had robbed him personally of a possible cure, that the adversaries he had battled in court all his career had somehow beaten him in the end.

Last summer, while on a respirator and feeding tube, he rode out Tropical Storm Fay. It flooded all the bedrooms of his house.

Last Friday, Gey's doctor told him his life had reached "the bottom of the eighth inning."

But he writes. His hands don't work, so he writes with his foot, guiding a computer mouse with his toes. He has just completed two 150-page works of constitutional scholarship. They're headed for the publisher. He also has lived long enough to see a new president reverse the government's standing on embryonic stem cell research.

Barbara Leach, a former student who now practices labor law in Atlanta, was with him just after he got his late-inning diagnosis.

"Bottom of the eighth?" she exclaimed, sitting among his mountains of manuscripts. "Looks to me like you're in the top of the third."

• • •

Third-year law student David Gillis brought his mother, Cathy, to the triathlon for Gey. He's one of the students who brings food to the professor's house. Dave's turn is every other Thursday.

When he started bringing food, he knew Gey mostly by reputation. It made him nervous. "He's this rock star of the legal profession."

Gey told Dave he liked anything, he wasn't fussy. Dave brought his personal favorite: takeout meat loaf from Boston Market.

"You getting tired of meat loaf?" he'd ask.

"No," Gey answered, "Love the meat loaf!"

Two months went by. Finally, Dave heard from a "second party." The professor was really, really tired of meat loaf.

But in the course of those months, Dave's own life changed. His mother said he had chosen law school for the career and for the money. That was it.

He got into Gey's constitutional law class. He admitted to Gey he was more interested in the lawyer trappings than in the law itself. Money's fine, the professor told him. "But where's your passion?"

Gey changed him. His mother could see it. He learned the impact that one lawyer could have. He felt part of something noble, he said. Gey changed her, too. At home in Sarasota she started mentoring.

"We've learned that's what life is about — passion," she said.

• • •

On Saturday afternoon, the students waited with cake and beer on Gey's porch. Gey had not been on his porch in months. But he had told them that if they could endure a triathlon, he could match them.

Inside the house, Gey took a deep breath and untethered his respirator. He swung his legs out of bed, steadied himself.

The double doors to the patio swung open.

Gey came through the doors, on his feet.

He walked a dozen steps across the deck to a chair.

Beers and tears flowed for two hours.

They sang Happy Birthday to You.

They told their professor: Sue us.

 

Train your brain: Can jogging make you smarter?

Physical activity boosts the flow of blood to the part of the brain that is responsible for memory and learning, promoting the production of new brain cells

Exercise won't just get you fit – it can also make you more intelligent. Simon Usborne discovers how to shape up your mind

We don't need to be told that exercise is good for us. We know that it combats cholesterol, we know boosts our hearts and we know it stops the pounds from piling on. But, beyond the obvious physical benefits of a good cycle, run or swim, a growing body of evidence suggests that getting breathless can also build the brain.

Spark: The Revolutionary New Science of Exercise and the Brain, which is published later this year, shows how even regular brisk walks can boost memory, alleviate stress, enhance intelligence and allay aggression. John Ratey, an associate professor of psychiatry at Harvard Medical School in Boston and the book's author, says that exercise stimulates our grey matter to produce what he calls "Miracle-Gro" for the brain. "I can't understate how important regular exercise is in improving the function and performance of the brain," he says. "It's such a wonderful medicine."

 

Happiness

If the mere thought of trudging round ice-bound playing fields at school was enough to bring you out in a cold sweat, the idea that exercise makes us happy might sound perverse. But, beyond the (potential) mood-lifting effects of fresh air and scenery, evidence suggests that pounding the pavement can also change the way our brains work to make us happier, or even stave off depression. "Exercise is as good as any anti-depressant I know," Ratey claims.

Last December, scientists from Yale University wrote in the journal Nature Medicine that regular exertion affects the hippocampus, the area of the brain responsible for mood. Tests on mice showed that exercise activated a gene there called VGF, which is linked to a "growth factor" chemical involved in the development of new nerve cells. Tests show that this brain activation lifts a person's mood. Participants in one recent German survey were asked to walk quickly on a treadmill for 30 minutes a day over a 10-day period. At the end of the experiment, researchers recorded a significant drop in depression scores. Scientists are now working on a drug that mimics the effects of the VGF gene to market it as an alternative to conventional antidepressants.

 

Stress

If, by around 4pm, it feels as if a stressful day at work has turned your brain to blancmange, it might not only be down to overwork or a shortage of double espressos. We respond to stress in the same way our ancestors did – by adopting a "fight or flight" response. Adrenalin and other hormones are released into our bloodstreams and our muscles are primed for response. The problem is that, these days, stress is more likely to be brought on by a tricky PowerPoint presentation or a job interview than an attack by marauding lions, so the toxins that build up for a physical response have no outlet. The results can be good; the cardiovascular system is accelerated and we can work harder (for a while, at least), but others are not so good; stress slows down the gastrointestinal system and reduces appetite, and can overexcite the brain, fuzzing our thought. By responding to or anticipating stress with fight (kickboxing or judo, say) or flight (30 minutes on the treadmill, say, or 50 lengths of the pool), blood flow to the brain is increased, allowing the body to purge the potentially toxic by-products of stress. According to Ratey, exercise also helps in the long term. "It builds up armies of antioxidants such as Vitamins E and C," he says. "These help brain cells protect us from future stress."

 

Intelligence

Observers of the game of football might refute the claim that exercise leads to greater intelligence – and they would be partly right, says Ratey. "Exercise doesn't make you smarter, but what it does do is optimise the brain for learning."

Physical activity boosts the flow of blood to the part of the brain that is responsible for memory and learning, promoting the production of new brain cells. Several schools in the US and the Netherlands have taken note. Pupils at Naperville Central High School near Chicago, for example, start the day with a fitness class they call "Zero Hour PE". Equipped with heart monitors, they run laps of the playground, and teachers say exam results have soared since the keep-fit initiative kicked off.

Meanwhile, in Amsterdam, a test involving 241 people, aged 15-71, compared physical activity with the results of cognitive tasks. The researchers documented improved results among people who were more active, especially those in younger age groups.

Yet more research suggests that exercise boosts intelligence in the very, very young. Experiments on rats at the Delbrück Centre for Molecular Medicine in Berlin showed that baby rats born to mothers who were more active during pregnancy had 40 per cent more cells in the hippocampus, the area of the brain responsible for intelligence. If the same is true in humans, we can expect Paula Radcliffe's baby, Isla, to be a genius; Radcliffe was training for the New York marathon until the day before she went in to hospital to be induced – and won the race just nine months after giving birth.

Aggression

A few rounds with a punch bag or a game of squash are great ways to release pent-up aggression, but exercise does more than "get it out your system", says John Ratey. "People assume exercise reduces aggression by burning energy. In fact, exercise changes your brain so you don't feel aggressive in the first place."

The frontal cortex is the part of the brain that decides whether you throw a punch or take something on the chin. Reduced activity in the region, a trauma or abnormal development can result in an inability to control violent urges. "This area makes us evaluate the consequences of our actions," Ratey says. "It's the part of the brain that puts the brakes on when the ref makes a terrible decision and you want to beat him up." Exercise increases activity in that area, boosting rational thought, which makesus less likely to lash out.

 

Memory

Most of the competitors at the annual World Memory Championships could hardly be described as the epitome of physical fitness but, according to Ratey and other scientists in the field, a good workout does much to boost recall, especially as we clock up the years.

"When we're exercising, we're using nerve cells in the brain which help build up what I call brain fertiliser," he says. Ratey is talking about new research that suggests exercise increases blood flow to the part of the brain responsible for memory, and improves its function. In MRI scans on mice, conducted last year by neurologists at Columbia University Medical Centre in New York, the animals were shown to grow new brain cells in the dentate gyrus, which is affected in age-related memory decline.

Research on humans is ongoing but Ratey is convinced that physical activity has a similar effect. He says: "Exercise does more than anything we know of to boost memory."

 

Addiction

Smokers keen to quit cigarettes probably won't celebrate the news that exercise could be the key to a fag-free life. But research by British scientists suggests that as little as five minutes of brisk walking can reduce the intensity of nicotine withdrawal symptoms. In the tests, researchers asked participants to rate their need for a cigarette after various types of physical exertion. Those who had exercised reported a reduced desire to smoke. "If we found the same effects in a drug, it would immediately be sold as an aid to help people quit smoking," Adrian Taylor, the study's lead author at the University of Exeter, said last year.

The principle is that exercise can stimulate production of the mood-enhancing hormone dopamine, which can, in turn, reduce smokers' dependence on nicotine. "Dopamine works by replacing or satisfying the need for nicotine," Ratey explains.

Whether the findings will lead office-based smokers to dash out for a jog remains to be seen. After all, you wouldn't want to get addicted to exercise.

How much do you need?

You don't have to become a marathon runner to benefit your brain. The mainstay of exercise is simple, brisk walking, Professor Ratey says.

You'll feel the benefit even from a 30-minute walk. "That's what people need to be doing as a minimum, ideally four or five times a week. If you want to do more, then great."

Professor Ratey also recommends interval training – really pushing yourself hard for between 20 and 30 seconds while running, cycling or swimming, so that you are momentarily exhausted.

Do, say, two minutes of walking, 30 seconds' sprinting, then two minutes of walking again. It doesn't have to be a lot for a long time, but you will really notice the difference. "The side effects on the body aren't bad either – I lost 10 pounds in no time," Professor Ratey says.

Runners’ High Demonstrated: Brain Imaging Shows Release Of Endorphins In Brain

 

Researchers have succeeded in demonstrating the existence of an 'endorphin driven runner's high'. (Credit: Arzt-Läufer, Image courtesy of University of Bonn)

ScienceDaily – Throughout the world, amateurs, experts and the media agree that prolonged jogging raises people's spirits. And many believe that the body's own opioids, so called endorphins, are the cause of this. But in fact this has never been proven until now. Researchers at the Technische Universität München and the University of Bonn succeeded in demonstrating the existence of an 'endorphin driven runner's high'. In an imaging study they were able to show, for the first time, increased release of endorphins in certain areas of the athletes' brains during a two-hour jogging session.

 

These results are also relevant for patients suffering from chronic pain, because the body's own opiates are produced in areas of the brain which are involved in the suppression of pain.

Runner's high

Endurance sports have long been seen as reducing stress, relieving anxiety, enhancing mood and decreasing the perception of pain. The high that accompanies jogging even led to the creation of its own term, 'runner's high'. Yet the cause of these positive effects on the senses was not clear until now. The most popular theory was and still is the 'Endorphin Hypothesis', which claimed that there was increased production of the body's own opioids in the brain. However, since until now direct proof of this theory could not be provided; for technical reasons, it was a constant source of controversial discussions in scientific circles. The result was that the myth of 'runner's high through endorphins' lived on.

Endorphin hypothesis confirmed

Scientists from the fields of Nuclear Medicine, Neurology and Anaesthesia at the Technische Universität München (TUM) and the University of Bonn have now subjected the endorphin theory to closer scrutiny. Ten athletes were scanned before and after a two-hour long-distance run using an imaging technique called positron emission tomography (PET). For this they used the radioactive substance [18F]diprenorphine ([18F]FDPN), which binds to the opiate receptors in the brain and hence competes with endorphins.

'The more endorphins are produced in the athlete's brain, the more opiate receptors are blocked,' says Professor Henning Boecker, who coordinated the research at TUM and who is now in charge of the 'Functional Neuroimaging Group' at the Dept. of Radiology, University Hospital Bonn. And further: 'Respectively the opioid receptor binding of the [18F]FDPN decreases, since there is a direct competition between endorphins in the brain and the injected ligand'.

By comparing the images before and after two hours of long distance running the study could demonstrate a significantly decreased binding of the [18F]FDPN-ligand. This is a strong argument in favour of an increased production of the body's own opioids while doing long-distance running. 'We could validate for the first time an endorphin driven runner's high and identify the affected brain areas', states Boecker. 'It's interesting to see that the affected brain areas were preferentially located in prefrontal and limbic brain regions which are known to play a key role in emotional processing. Moreover, we observed a significant increase of the euphoria and happiness ratings compared to the ratings before the running exercise.'

Professor Thomas Tölle, who for several years has been head of a research group called 'Functional Imaging of Pain' at TU Munich, adds: 'Our evaluations show that the more intensively the high is experienced, the lower the binding of [18F]FDPN was in the PET scan. And this means that the ratings of euphoria and happiness correlated directly with the release of the endorphins.' This has clear implications for those who suffer from chronic pain. 'The fact that the endorphins are also released in areas of the brain that are at the centre of the suppression of pain was not quite unexpected, but even this proof was missing. Now we hope that these images will also impress our pain patients and will motivate them to take up sports training within their available limits,' he concluded.

Running down the pain?

It is well known that endorphins facilitate the body's own pain suppression by influencing the way the body passes on pain and processes it in the nervous system and brain. The increased production of endorphins resulting from long-distance running could also serve as the body's own pain-killer, a potent potential therapeutic option. 'Now we are very curious about the results of an imaging study using Functional Magnetic Resonance Imaging which we are currently carrying out in Bonn in order to investigate the influence of long-distance running on the processing of pain directly,' Professor Boecker says.

Further research is required so as to investigate the exact effects on depression and states of anxiety but also on possible aspects which may promote addiction. That is why the relation between genetic disposition and opiate receptor distribution in the brain is being currently investigated at TU Munich. 'A scary thought,' Thomas Tölle comments, 'if we ran because our genes wanted us to do so.' The first step towards researching these connections has now been made.

The results of the study " The Runner's High: Opioidergic Mechanisms in the Human Brain" are published in the journal 'Cerebral Cortex'. This research was supported by the German Research Association, as well as the Federal Ministry of Education and Research and the German Association of Neuropathic Pain. 

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Humans hot, sweaty, natural-born runners

Source: Harvard University

Hairless, clawless, and largely weaponless, ancient humans used the unlikely combination of sweatiness and relentlessness to gain the upper hand over their faster, stronger, generally more dangerous animal prey, Harvard Anthropology Professor Daniel Lieberman said Thursday (April 12).

Just days before Monday’s 111th running of the Boston Marathon, Lieberman presented his theories of the importance of running to ancestral humans to explain why we’re the only species that voluntarily runs extraordinarily long distances, such as the 26.2 miles in the marathon.

The talk, “Why Humans Run: The Biology and Evolution of Marathon Running,” was delivered at the Geological Lecture Hall as part of the Harvard Museum of Natural History’s spring lecture series, “Evolution Matters.”

While more than a million humans run marathons voluntarily each year, most animals we consider excellent runners — antelopes and cheetahs, for example — are built for speed, not endurance. Even nature’s best animal distance runners — such as horses and dogs — will run similar distances only if forced to do so, and the startling evidence is that humans are better at it, Lieberman said.

Modern humans and their immediate ancestors such as Homo erectus sport several adaptations that make humans, instead of some ferocious, furry, or fleet creature, the animal world’s best distance runners.

“Humans are terrible athletes in terms of power and speed, but we’re phenomenal at slow and steady. We’re the tortoises of the animal kingdom,” Lieberman said.

That evidence belies the long and firmly held belief that humans are the animal world’s biggest wimps and, if not for our big brains and advanced weapons, we’d be forced to subsist on fruits and vegetables, always in danger of being gobbled up by fiercer predators.

The problem with that theory, Lieberman said, is that we began adding meat to our diets around 2.6 million years ago, long before we developed advanced weapons like the bow and arrow, which was developed as recently as 50,000 years ago.

While some of our ancestors’ meat-eating may have been due to scavenging, Lieberman said the appearance about 2 million years ago of physical adaptations that have no impact on walking but that make humans better endurance runners provide evidence that early scavengers became running hunters.

Specifically, we developed long, springy tendons in our legs and feet that function like large elastics, storing energy and releasing it with each running stride, reducing the amount of energy it takes to take another step. There are also several adaptations to help keep our bodies stable as we run, such as the way we counterbalance each step with an arm swing, our large butt muscles that hold our upper bodies upright, and an elastic ligament in our neck to help keep our head steady.

Even the human waist, thinner and more flexible than that of our primate relatives allows us to twist our upper bodies as we run to counterbalance the slightly-off-center forces exerted as we stride with each leg.

Once humans start running, it only takes a bit more energy for us to run faster, Lieberman said. Other animals, on the other hand, expend a lot more energy as they speed up, particularly when they switch from a trot to a gallop, which most animals cannot maintain over long distances.

Though those adaptations make humans and our immediate ancestors better runners, it is our ability to run in the heat that Lieberman said may have made the real difference in our ability to procure game.

Humans, he said, have several adaptations that help us dump the enormous amounts of heat generated by running. These adaptations include our hairlessness, our ability to sweat, and the fact that we breathe through our mouths when we run, which not only allows us to take bigger breaths, but also helps dump heat.

“We can run in conditions that no other animal can run in,” Lieberman said.

While animals get rid of excess heat by panting, they can’t pant when they gallop, Lieberman said. That means that to run a prey animal into the ground, ancient humans didn’t have to run further than the animal could trot and didn’t have to run faster than the animal could gallop. All they had to do is to run faster, for longer periods of time, than the slowest speed at which the animal started to gallop.

All together, Lieberman said, these adaptations allowed us to relentlessly pursue game in the hottest part of the day when most animals rest. Lieberman said humans likely practiced persistence hunting, chasing a game animal during the heat of the day, making it run faster than it could maintain, tracking and flushing it if it tried to rest, and repeating the process until the animal literally overheated and collapsed.

Most animals would develop hyperthermia — heat stroke in humans — after about 10 to 15 kilometers, he said.

By the end of the process, Lieberman said, even humans with their crude early weapons could have overcome stronger and more dangerous prey. Adding credence to the theory, Lieberman said, is the fact that some aboriginal humans still practice persistence hunting today, and it remains an effective technique. It requires very minimal technology, has a high success rate, and yields a lot of meat.

Lieberman said he envisions an evolutionary scenario where humans began eating meat as scavengers. Over time, evolution favored scavenging humans who could run faster to the site of a kill and eventually allowed us to evolve into persistence hunters. Evolution likely continued to favor better runners until projectile weapons made running less important relatively recently in our history.

“Endurance running is part of a suite of shifts that made Homo [the genus that includes modern people] human,” Lieberman said.