Is running good for weight loss in your legs?

I’d like to either lose weight in my legs, or at least tone them nicely. Even if they remain about the same size but turn to muscle I’m fine with that.

Would running with a Wii fit work to achieve this if I only run for 10-20 minutes a day? I have a disability which prevents me from doing more than that unfortunately. Will this be sufficient enough to achieve weight loss in my legs or tone them, or is there nothing I can do since I can’t push myself more than that?

Thanks!